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Premier Lecture Series

The chromosome territory interchromatin compartment (CT-IC) model argues for a functional organization of the cell nucleus. Chromosome territory (CT) arrangements show profound differences between certain cell types. In the spherically shaped lymphocyte nuclei gene dense CTs are preferentially located in the nuclear interior, while gene poor CTs are preferentially located towards the nuclear pe...

Premier Lecture Series

Tissue microarray technology has emerged as a powerful tool for measuring tumor-specific protein expression and linking it to clinical outcome. Automated quantitative analysis of the tissue spots take the technology one step further, removing observer bias, providing standards for quality control and providing for high throughput analysis. We have developed a platform (PM1000) and software (AQU...

Premier Integration White Paper

Premier Lecture Series

Lung cancer is the most common cause of cancer death worldwide, and the majority of cases are associated with cigarette smoking. Non-small cell lung cancer (NSCLC) arising in smokers has a different spectrum of molecular abnormalities than does NSCLC arising in non-smokers, suggesting differences in molecular etiology, pathogene-sis and possibly prognosis. For example, KRAS mutations occur in 2...